The submembrane machinery for nicotinic acetylcholine receptor clustering.
نویسندگان
چکیده
منابع مشابه
The submembrane machinery for nicotinic acetylcholine receptor clustering
T HE segregation of membrane proteins into specialized domains is important for many aspects of cell function, especially those involving cell-cell interaction and conununication . Of particular interest to cellular and molecular neurobiologists are the highly specialized distributions of ion channels at synapses . Both the preand postsynaptic membranes exhibit organized arrays ofion channels t...
متن کاملEmbedded cholesterol in the nicotinic acetylcholine receptor.
The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that spanned several decades [Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4 A resolution. J Mol Biol 346:967-989]. Purified nAChR must...
متن کاملConformation of acetylcholine bound to the nicotinic acetylcholine receptor.
We report here the biologically active conformation of acetylcholine when bound to the high-affinity state of the receptor from Torpedo californica. The acetylcholine conformation was determined in the free and bound states by proton NMR two-dimensional nuclear Overhauser effects. In agreement with x-ray crystallographic data, acetylcholine in solution has an extended conformation with an avera...
متن کاملDeterminants Responsible for Assembly of the Nicotinic Acetylcholine Receptor
The assembly of the four homologous, but distinct, a , b , g , and d subunits of the nicotinic acetylcholine receptor (nAChR) into the pentamer a 2 bgd presents a unique opportunity to delineate the individual amino acid side chains that contribute to the assembly process, and to examine the pathway responsible for subunit assembly and expression at the cell surface. It is well established that...
متن کاملLipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering.
Agrin, a motoneuron-derived factor, and the muscle-specific receptor tyrosine kinase (MuSK) are essential for the acetylcholine receptor (AChR) clustering at the postjunctional membrane. However, the underlying signaling mechanisms remain poorly defined. We show that agrin stimulates a dynamic translocation of the AChR into lipid rafts-cholesterol and sphingolipid-rich microdomains in the plasm...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1991
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.114.1.1